| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2455367 | Research in Veterinary Science | 2011 | 5 Pages |
Abstract
The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal growth plate in submuscular transplantation (ectopic osteoinduction) as a new xenogenic biomaterial in rat model. Demineralized bovine foetal growth plate was ectopically implanted in 18 male Sprague-Dawley rats. In 18 of the animals under aseptic conditions two submuscular pouches were created between external and internal oblique abdominal muscles in the two flanks: the right was left empty (sham) and the left was filled with 20Â mg of demineralized bovine foetal growth plate powder. Radiographs were taken in 2, 4 and 6Â weeks after the surgery, then six animals were pharmacologically euthanized after 2, 4 and 6Â weeks for histopathological evaluation. Results showed: (1) osteoinductivity of xenogenic demineralized bovine foetal growth plate powder, and (2) earlier mineralization of ectopically implanted demineralized bovine foetal growth plate in the submuscular implanted area. Our results show that submuscular implantation of xenogenic demineralized bovine foetal growth plate has osteoinductive properties in a rat model.
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Authors
A.S. Bigham, M. Shadkhast, A. Bigham Sadegh, Z. Shafiei, A. Lakzian, M.R. Khalegi,