| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2455409 | Research in Veterinary Science | 2012 | 4 Pages |
Abstract
γδ T cells represent an unconventional subset of T lymphocytes that are abundant in epithelial tissues and serve as an early immune defense against microbes. We have, for the first time, identified γδ T cells in steady-state thoracic duct lymph (TDL) from rats. The lymph contains γδ T cells expressing CD8 but not CD4, CD25, MHC-II or CD103. The percentage of TDL γδ T cells in rats does not change when the mesenteric lymph nodes (MLN) are surgically removed. Our data suggest that a proportion of γδ T cells migrate from the intestine into rat TDL, under steady-state conditions.
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Authors
Sudhanshu Shekhar, Simon Milling, Chris Jenkins, Gordon MacPherson,