Article ID Journal Published Year Pages File Type
2455436 Research in Veterinary Science 2012 10 Pages PDF
Abstract

The aim of this prospective study was to characterize the response of the coagulation system to a defined sterile localized inflammatory process.Tissue cages were implanted subcutaneously in five healthy Beagles. After 9–10 weeks, local inflammation was induced by an injection of 0.5 ml 1% carrageenan. Serial samples of tissue cage fluid (TCF) and blood were collected at 10 time points (0–168 h). Nucleated cells (NC) of TCF were counted automatically to characterize local inflammation. C-reactive protein (CRP), leukocytes and coagulation variables (PT, aPTT, fibrinogen, factor VIII, antithrombin, protein C, protein S, and d-dimers) were determined in blood samples.Carrageenan induced a significant 32-fold increase of NCs in TCF (P < 0.0001). A slight increase in leukocytes (P < 0.0001) was observed. There was a significant 1.3- to 1.5-fold increase in protein C (P = 0.0001) and protein S (P = 0.0028). CRP, secondary hemostasis and fibrinolysis did not change.The mild increase from baseline in PC/PS, may reflect a physiological counter reaction.

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