Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2456118 | Research in Veterinary Science | 2009 | 7 Pages |
Abstract
A DNA vaccine against contagious agalactia was developed for the first time, encoding the P48 of Mycoplasma agalactiae. Specific immune responses elicited in BALB/c mice were evaluated. Both total IgG and IgG1 were detected in mice vaccinated with pVAX1/P48. Proliferation of mononuclear cells of the spleen, levels of gamma interferon, interleukin-12, and interleukin-2 mRNAs were enhanced in immunized animals. Results indicate that pVAX1/P48 vaccination induced both Th1 and Th2 immune responses. Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases.
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Authors
Bernardo Chessa, Marco Pittau, Maria Puricelli, Rosanna Zobba, Elisabetta Coradduzza, Paola Dall’Ara, Sergio Rosati, Giorgio Poli, Alberto Alberti,