The effect of diet type on the plasma disposition of triclabendazole in goats

The effect of two different diet types (concentrate feed + hay and grazing) on the pharmacokinetic profiles of triclabendazole following oral administration in goats was investigated. A total of 12 goats were randomly allocated into two groups which were either indoor and fed concentrate + hay ration (housed group) or were grazing on pasture (grazing group). Triclabendazole was administered orally to animals in two groups at 10 mg/kg bodyweight. Blood samples were collected from 1 h to 192 h post-treatment and analyzed by high performance liquid chromatography (HPLC). Feeding with different diets significantly effected the plasma disposition of triclabendazole sulphoxide. Maximum plasma concentration (Cmax: 13.22 ± 2.81 μg/ml), time to reach maximum plasma concentration (tmax: 18.4 ± 2.19 h), area under the curve (AUC: 613 ± 137 μg h/ml), half-life (t1/2: 24.77 ± 1.94 h) and mean resident time (MRT: 40.22 ± 4.36 h) of triclabendazole sulphoxide in housed group were significantly different from those of grazing group (Cmax: 10.17 ± 1.51 μg/ml, tmax: 14.0 ± 2.19 h, AUC: 406 ± 98 μg h/ml), t1/2: 16.16 ± 1.17 h and MRT: 34.48 ± 4.40 h). It is concluded that anthelmintically more active sulphoxide metabolite has higher plasma concentration when triclabendazole is administered to goats fed with concentrate feed + hay compared to grazing goats.