| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2456748 | Small Ruminant Research | 2016 | 5 Pages |
•Vaccine response to PPRV vaccine is highly variable and influenced by environmental and genetic components.•Higher Pre-vaccination titre is indicative of maternal antibody titre in lambs. This in turn affect the PPR vaccine response at 28 days post vaccination.•Moderate estimate of heritability for vaccine response augurs selection of goats for higher response.
Peste des petits ruminants (PPR) is a devastating disease of small ruminants in India due to its spread and economic importance. Vaccination with attenuated whole virus vaccine is the only strategy adopted for prevention of this disease. Present study was carried out to identify the sources of variation and also to unravel the genetic variance in the PPR virus (PPRV) vaccine elicited immune response in 374 Sirohi goat kids maintained at an organized institute flock in the semi-arid region of India. Average age at vaccination was 142.43 days. Sera were tested by competitive ELISA (C-ELISA), an attenuated PPRV (Sungri) was used as the coating antigen. Results revealed significant variability for response to vaccination. Per cent inhibition (PI) values at 0 day of vaccination (0DPrV) was 22.50% and at 28 days post vaccination (28DPV) it was 71.8%. On 28DPV, 94.92% of the total animals showed protective titre. Among environmental determinants, cohort and age at vaccination proved to be significant sources of variation (P < 0.05). Higher 0DPrV titre was found to affect 28DPV titre negatively. Factors determining the better odds of protection needs to be exploited properly to assure protection. The estimate of heritability (h2 ± SE) at 0DPrV was 0.00 ± 0.12, however it revealed significant contribution from maternal permanent environment (c2 = 0.38 ± 0.12). At 28DPV, h2 was 0.34 ± 0.16 and c2 was 0.25 ± 0.15.
