Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2461282 | Veterinary Immunology and Immunopathology | 2016 | 6 Pages |
Abstract
This analysis revealed differences in cytokine groups between dogs with sepsis and IMHA when compared to healthy control dogs but no difference between dogs with either of these conditions. In conclustion, dogs in the early stage of sepsis and IMHA have similar circulating cytokines despite different etiologies suggesting activation of common immunologic pathways. This may have implications for immunotherapy of immune mediated diseases in dogs of varying etiology.
Keywords
TNFαLPSgranulocyte monocyte colony stimulating factorMODSIFNγTGFβSIRSMCP-1GM-CSFinterleukinBacteriaTransforming Growth Factor Betatumor necrosis factor alphaautoimmunityIMHAMultiple organ dysfunction syndromeSystemic inflammatory response syndromeInfectionlipopolysaccharideHost responsemonocyte chemoattractant protein 1ChemokineInterferon gamma
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Authors
Valerie Johnson, Brandy Burgess, Paul Morley, Ryan Bragg, Anne Avery, Steven Dow,