| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2463192 | Veterinary Immunology and Immunopathology | 2007 | 6 Pages |
Abstract
Canine cutaneous histiocytoma (CCH) has been identified as a tumour of epidermal Langerhans cells (LCs) on the basis of immunophenotypic studies. Neoplastic Langerhans cells (CCH-LCs) were isolated from lesions of canine cutaneous histiocytoma. The CCH-LC cells expressed CD1b, CD11/18, CD45, MHC-I, and MHC-II. The CCH-LC cells were potent stimulators of the mixed leucocyte reaction (MLR) in vitro when compared to PBMCs from the tumour-bearing animals. This provides evidence that the neoplastic cells in CCH have functional as well as immunophenotypic characteristics of Langerhans cells.
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Authors
S.J. Baines, B.A. Blacklaws, E. McInnes, I.M. McConnell,