| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2463843 | The Veterinary Journal | 2015 | 6 Pages |
•Mesenchymal stem cells are obtained from various tissues and donor attributes have implications for therapeutic potential.•The proposed mechanism of action of mesenchymal stem cells and their potential for renal repair is discussed.•Studies in rodents show marked potential for palliation of chronic kidney disease.•Clinical trials in feline patients have not demonstrated the same degree of efficacy seen in rodent studies.•Great potential exists for this treatment modality but additional study is required.
Stem cell therapy is an innovative field of scientific investigation with tremendous potential for clinical application that holds promise for the treatment of a variety of diseases in veterinary medicine. Based on the known desirable properties of mesenchymal stem cells, the therapy has potential for treatment of both acute kidney injury and chronic kidney disease in cats. This review details terminology commonly used in this field of study, sources of mesenchymal stem cells and their proposed mechanism of action particularly as it relates to renal repair. Studies performed in rodent models of chronic kidney disease and feline clinical trial results are also summarized with the aim of providing an overview of the current status of this treatment modality and its potential for the future.
