Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2464886 | The Veterinary Journal | 2009 | 6 Pages |
Abstract
The hearts of the GH dogs had larger atria (+22%), a thicker left ventricular wall (+21%), greater weight (+84%), and their cardiomyocytes were 15% longer, 25% thicker, and 92% greater in volume than those of control dogs. The mean collagen fraction was also higher in the GH dogs (5.6%) than in the controls (3.1%). In conclusion, excess GH in juvenile miniature poodles resulted in myocardial hypertrophy and increased collagen content. These findings are consistent with observations in acromegalic human patients and in rats treated with GH.
Keywords
Related Topics
Life Sciences
Agricultural and Biological Sciences
Animal Science and Zoology
Authors
Annemarie R. Vegter, Matthijs F.M. van Oosterhout, Bregje J.P. Verhoeven, Meropi A. Tryfonidou, Susanne A.E.B. Boroffka, Arnold A. Stokhof,