Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2469054 | Veterinary Microbiology | 2007 | 8 Pages |
Abstract
The epitopes of the capsid of foot-and-mouth disease virus (FMDV) play important roles in the construction of highly immunogenic subunit vaccines. However few epitopes have been found for FMDV serotype Asia1. In this study we screened for epitopes of the VP1 and VP2 proteins of FMDV serotype Asia1 isolate, YNBS/58. Fragments consisting of amino acids 133–163 of VP1 and amino acids 1–33 of VP2 contained epitopes, and both induced lymphoproliferation in guinea pigs. Only the VP1 fragment induced neutralizing antibodies but the VP2 peptide dramatically increased the neutralizing antibody response induced by the VP1 peptide.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Animal Science and Zoology
Authors
Jia-Long Wang, Ming-Qiu Liu, Ji Han, Wei-Zao Chen, Wei Cong, Gong Cheng, Yan-Hua Gao, Yong-Gan Lu, Jiu-Lian Chen, Xiao-Ping Zuo, Wei-Yao Yan, Zhao-Xin Zheng,