Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2470081 | Veterinary Parasitology | 2013 | 6 Pages |
Abstract
Infection of mice with Trichinella spiralis redirects the mucosal immune system from a Th1 to a protective Th2 response with a reduction in the severity of trinitrobenzesulfonic acid-induced colonic damage. T. spiralis infection induced IL-10 production in a dose-dependent manner in oxazolone (OXZ)-induced colitis. This phenomenon may be responsible for the lack of efficacy of T. spiralis in the treatment of OXZ-induced colitis. These results indicate that if the source of increased IL-10 production is identified and addressed, T. spiralis may alter the Th2 response.
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Authors
Y. Zhao, M.Y. Liu, X.L. Wang, X.L. Liu, Y. Yang, H.B. Zou, S.M. Sun, L. Yu, B. Rosenthal, H.N. Shi, P. Boireau, X.P. Wu,