Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2474247 | Ticks and Tick-borne Diseases | 2013 | 4 Pages |
Abstract
Prior exposure of vertebrate hosts to tick salivary proteins can induce specific immunity to tick infestation, as well as affording protection against tick-transmitted Borrelia burgdorferi infection in the mammalian host. Vaccination using an adenovirus expression system to deliver 4 tick salivary proteins (Ad-Salps) derived from Ixodes scapularis, Salp15, Salp25A, Salp25D, and Isac, was explored. Results indicate that vaccination with tick salivary proteins in an adenoviral vector can be used to modulate a Th1 response in the host and partially control spirochete load in immunized mice after infected tick challenge.
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Authors
A.J. Ullmann, M.C. Dolan, C.A. Sackal, E. Fikrig, J. Piesman, N.S. Zeidner,