| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2474565 | Acta Pharmaceutica Sinica B | 2014 | 5 Pages |
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
Graphical abstract2-Hydroxytyrosol (2-HT), was found to inhibit mushroom tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
