Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2498807 | Experimental and Toxicologic Pathology | 2015 | 7 Pages |
Abstract
Thiazole-Zn is a newly created Chinese systemic fungicide that is a thiadiazole compound. The toxicity of thiazole-Zn was examined in Sprague-Dawley rats fed diets containing 0, 4, 20 and 100Â mg/kg thiazole-Zn for one year. Lower body weight gains were noted in both males and females of the 100Â mg/kg diet group. Moreover, we show that the toxicity of thiazole-Zn was low, as evidenced by the absence of toxicologically significant changes in the general condition and appearance, hematology and clinical chemistry parameters, organ weights and necropsy findings of the rats. Thyroid follicular cell hyperplasia was the only finding of potential significance. The incidence of thyroid follicular cell hyperplasia significantly increased in high-dose males (4/10) and females (3/10) at the 26-week interim examination; one follicular adenoma in the thyroid was observed in high-dose males. At 52 weeks, the incidence of thyroid follicular cell hyperplasia was significantly higher in high-dose males (4/10) and females (4/10) than in the controls. Two thyroid follicular adenomas were observed in high-dose males. Other treatment-related effects and tumors at other sites were not observed. This study suggests that thiazole-Zn is a thyroid disrupter and likely a rat thyroid carcinogen.
Keywords
PLTGLBPCTMCVMPVMCHCPDWCREAMCHALTRBCHCTWBCALBA/GT-BILASTAspartate aminotransferaseAlanine aminotransferaseAlbuminalbumin/globulinALPAlkaline phosphataseUreaChoLymphocyte countMean corpuscular volumeChronic toxicityPlatelet distribution widthmean platelet volumemean corpuscular hemoglobinMonocyteMean corpuscular hemoglobin concentrationHemoglobinHgbPlateletcritPlateletcreatininetotal bilirubintotal proteincholesterolGranulocytewhite blood cellred blood cellGluGlucose
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Authors
Honglian Yang, Qingxi Kong, Huanliang Liu, Wei Zhang, Lei Tian, Bencheng Lin, Yanjun Fang, Zhuge Xi,