| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2498937 | Experimental and Toxicologic Pathology | 2014 | 6 Pages |
Abstract
Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.
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Authors
Yuanlin Qi, Hui Li, Mingfang Zhang, Tao Zhang, Jacqueline Frank, Gang Chen,