Article ID Journal Published Year Pages File Type
2498964 Experimental and Toxicologic Pathology 2014 6 Pages PDF
Abstract

•Apoptosis and necrosis are typical pathological features of liver diseases.•Apoptosis and necrosis represent alternative outcomes of different etiology during liver injury.•Therapeutic options of liver disease depend on the understanding toward pathogenic mechanisms of different etiology.

Hepatic apoptosis is thought of as a prevalent mechanism in most forms of liver injury. However, the role of hepatic apoptosis is often intermixed with the cellular necrosis. It remains unknown how apoptosis is relevant to the progression of the liver injury. This review summarizes the characteristics of both hepatic apoptosis and necrosis in pathogenesis of liver diseases. Apoptosis and necrosis represent alternative outcomes of different etiology during liver injury. Apoptosis is a main mode of cell death in chronic viral hepatitis, but is intermingled with necrosis in cholestatic livers. Necrosis is the principal type of liver cell killing in acetaminophen-induced hepatotoxicity. Anti-apoptosis as a strategy is beneficial to liver repair response. Therapeutic options of liver disease depend on the understanding toward pathogenic mechanisms of different etiology.

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