Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2499557 | Experimental and Toxicologic Pathology | 2006 | 8 Pages |
Abstract
The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 μg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
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Authors
Sun-A Cho, Jong-Hwan Park, Seung-Hyeok Seok, Jae-Hyeon Juhn, Seong-Jin Kim, Hyi-Jeong Ji, Youn-Sung Choo, Jae-Hak Park,