Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2499914 | Experimental and Toxicologic Pathology | 2007 | 5 Pages |
Abstract
A spontaneous mammary gland ductal carcinoma was diagnosed in a 13-year-old female captive rhesus monkey (Macaca mulatta). The expression of argyrophilic nucleolar organizer regions (AgNORs) was studied to investigate the correlation between the histologic invasiveness and cell proliferation activity assay for predicting the biologic behavior of this tumor type. The results of this study show that the AgNOR size in tumor cells reflect the degree of malignancy when compared with the pattern of peripheral blood lymphocytes of the same individual. This is the first study showing a significant AgNOR feature of a malignant breast tumor in a rhesus monkey and it longs to provide additional diagnostic tool in tumor pathology.
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Authors
Beatriz Goldschmidt, Renato Sergio Marchevsky, Marcia Cristina Ribeiro Andrade, Claudia Andréia de Araújo Lopes, Miguel Ângelo Bruck Gonçalves, Antonio da Mota Marinho, Taya Figueiredo de Oliveira,