Phenylpropanoids and neolignans from Smilax trinervula

A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(β-d-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9′-tetrahydroxy-3, 5, 3′, 5′-tetramethoxy-8-4′-oxyneolignan 4-O-β-d-glucopyranoside (2) and 3′, 9, 9′-trihydroxy-3, 5-dimethoxy-8-O-4′-neolignan-4-O-β-d-glucopyranoside (3), together with a new natural product (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-1, 2, 3-propanetriol (4) and four known compounds (5–8) were isolated from the rhizomes of Smilax trinervula. Their structures were established mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1–8 were tested in vitro for their cytotoxic activities against 5 human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo and Vero). Compounds 7 and 8 exhibited cytotoxic activity against Lovo, with IC50 values of 18.7 μM and 16.8 μM, respectively.

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