| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538531 | Fitoterapia | 2014 | 7 Pages |
Abstract
Seven new ent-kaurane diterpenoids, isowikstroemins A–G (1–7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1–4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 μM. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages.
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Authors
Hai-Yan Wu, Wei-Guang Wang, Hua-Yi Jiang, Xue Du, Xiao-Nian Li, Jian-Xin Pu, Han-Dong Sun,