Four new neolignans from the leaves of Tripterygium wilfordii

Four new neolignans, wilfordiols A–D (1–4), together with five known compounds (5–9), were isolated from an aqueous extract of the dried leaves of Tripterygium wilfordii. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The anti-inflammation activities of compounds 1–9 were evaluated by the inhibitory effect on NO production, in vitro.

Graphical abstractFour new neolignans were isolated from the leaves of Tripterygium wilfordii, together with five known lignans and neolignans. In an in vitro bioactive assay, some compounds exhibited anti-inflammatory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide