Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2548795 | Journal of Pharmacological Sciences | 2015 | 5 Pages |
Abstract
This study aimed to elucidate the protective potential of angiostatin in inflamed endothelial cells in culture. We assessed the effect of angiostatin on the expression of ICAM-1 and eNOS. Angiostatin prevented IL-1β-induced down-regulation of eNOS expression, but produced no significant changes on IL-1β-induced up-regulation of ICAM-1. We then explored the effect of angiostatin on IL-1β-mediated inflammatory signaling and found that angiostatin inhibited IL-1β-mediated nuclear translocation of NF-κB. Thus, our results suggest that angiostatin prevents IL-1β-induced down-regulation of eNOS expression via inhibition of the NF-κB cascade; this may be the anti-inflammatory mechanism of angiostatin.
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Authors
Yasushi Kawasaki, Eriko Yokobayashi, Kentaro Sakamoto, Eri Tenma, Haruka Takaki, Yuki Chiba, Tomomi Otashiro, Mai Ishihara, Sei Yonezawa, Akinori Sugiyama, Yasuhiro Natori,