Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2548831 | Journal of Pharmacological Sciences | 2015 | 4 Pages |
Abstract
Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice. Electrophysiological analyses revealed that mAChR stimulation enhanced intestinal chloride secretion, which was further augmented by the inhibition of JNK but not by that of ERK or p38 with specific inhibitors SP600125, U0126 or SB203580, respectively. Immunoblot analyses in colonic mucosa showed that mAChR stimulation increased MAPKs phosphorylation that was suppressed by the specific inhibitor for each MAPK. This suggests that JNK is a major negative regulator in mAChR-induced intestinal secretion.
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Authors
Md Rafiqul Islam Khan, Md Tariqul Islam, Takashi Yazawa, Hisayoshi Hayashi, Yuichi Suzuki, Junsuke Uwada, Abu Syed Md Anisuzzaman, Takanobu Taniguchi,