Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2548848 | Journal of Pharmacological Sciences | 2015 | 4 Pages |
Abstract
In order to investigate how IKr and IKs inhibitions affect waveforms of the field potential in the human iPS cell-derived cardiomyocytes sheet, we analyzed the effects of E-4031 and chromanol 293B on the maximum upslope and peak amplitude of its second wave (n = 7 for each drug). E-4031 in 10–100 nM as well as chromanol 293B in 3–30 μM prolonged the field-potential duration, whereas E-4031 decreased the upslope in 10–100 nM and amplitude at 100 nM, which was not observed by chromanol 293B. Thus, the decrease of the upslope can be used as a supplemental marker of drug-induced IKr inhibition.
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Authors
Junko Matsuo, Yuji Nakamura, Hiroko Izumi-Nakaseko, Kentaro Ando, Yuko Sekino, Atsushi Sugiyama,