Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2823229 | Infection, Genetics and Evolution | 2010 | 4 Pages |
Abstract
Standard anti-tuberculosis (TB) drug therapy had distinct effects on the bacilli burden in mice of DBA/2, C3H, SWR/J, and C57BL/6 inbred strains. To standardize the TB infection process, susceptible DBA/2 mice were infected with 1/10 of the dose used for relatively resistant C57BL/6 mice, such that the lung CFUs were roughly identical 3 weeks after infection when therapy was initiated. We found that TB treatment was more effective in the susceptible DBA/2 mice than in the relatively resistant C57BL/6 mice.
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Authors
Boris V. Nikonenko, Leo Einck, Carol A. Nacy,