Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2823345 | Infection, Genetics and Evolution | 2009 | 16 Pages |
Abstract
Since the first description of a polyomavirus a half-century ago in 1953, a multiplicity of human and animal polyomaviruses have been discovered. After reviewing the history of research into this group, with a special focus is made on the clinical importance of human polyomaviruses, we conclude by elucidating the phylogenetic relationships and thus evolutionary history of these viruses. Our phylogenetic analyses are based on all available putative polyomavirus species as well as including all subtypes, subgroups, and (sub)lineages of the human BK and JC polyomaviruses. Finally, we reveal that the hypothesis of a strict codivergence of polyomaviruses with their respective hosts does not represent a realistic assumption in light of phylogenetic findings presented here.
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Authors
Andi Krumbholz, Olaf R.P. Bininda-Emonds, Peter Wutzler, Roland Zell,