Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2825737 | Trends in Plant Science | 2016 | 11 Pages |
Aurora kinases are evolutionarily conserved key mitotic determinants in all eukaryotes. Yeasts contain a single Aurora kinase, whereas multicellular eukaryotes have at least two functionally diverged members. The involvement of Aurora kinases in human cancers has provided an in-depth mechanistic understanding of their roles throughout cell division in animal and yeast models. By contrast, understanding Aurora kinase function in plants is only starting to emerge. Nevertheless, genetic, cell biological, and biochemical approaches have revealed functional diversification between the plant Aurora kinases and suggest a role in formative (asymmetric) divisions, chromatin modification, and genome stability. This review provides an overview of the accumulated knowledge on the function of plant Aurora kinases as well as some major challenges for the future.
TrendsAurora kinases are key mitotic regulators in plants.α-Aurora and β-Aurora kinases from plants are functionally divergent.Plant Aurora kinases differ from their animal counterparts.Aurora kinases have diverse roles throughout plant development.Formative divisions require higher mitotic kinase levels than do proliferative divisions.