Disturbances in core body temperature in RIP140-null mice

1.RIP140-null mice have reduced core body temperature (Tc), but exhibit normal temperature increase in response to stress, and normal upregulation of UCP1 mRNA in brown adipose tissue (BAT) after β3-AR agonist treatment.2.Expression levels of some genes key to BAT function are altered in RIP140-null mice, including PGC1α.3.Newborn RIP140-null mice have reduced BAT mass, altered BAT gene expression and a high death rate.4.Differences in anxiety behavior and activity also exist in RIP140-null mice.5.Our observations suggest that RIP140 is involved in a broad range of systems critical to energy balance, thermoregulation, BAT development and behavior.