Expression of the 1A and 2A serotonin receptor genes in the brain of rats adapted to warm and cold

1.The effect of long-term thermal adaptation on expression of 5-HT1A and 5-HT2A receptor genes was studied by quantitative RT-PCR in brain regions of rats adapted for 5 weeks to warm (+20 to +22 °C) or cold (+4 to +6 °C).2.No differences were found in the 5-HT1A receptor mRNA levels in the rats of two groups.3.The 5-HT2A receptor mRNA levels in cold-adapted rats in comparison to warm-adapted rats increased in hypothalamus and decreased in frontal cortex, but were unaltered in hippocampus.