Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3311377 | Hepatology Research | 2006 | 11 Pages |
Abstract
Advances in biotechnology have allowed hepatocyte transplantation as a relevant proposition to treat liver disease. This procedure may change the crescent mortality in liver transplantation waiting lists due global organ shortage. Recent clinical trials have described promising results of hepatocyte transplantation for acute, acute-on-chronic and metabolic liver disease. In this report, we discuss progresses regarding hepatocyte culture, cryopreservation systems, hepatocyte immortalization, suitable recipient site for hepatocyte engraftment, cell differentiation and fusion into hepatocytes, current clinical trials, and summarize the bioartificial liver systems. These progressions motivate expectation concerning hepatocyte transplantation as a consistent therapy for liver disease.
Keywords
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Authors
Flávio Henrique Ferreira Galvão, Dahir Ramos de Andrade Júnior, Dahir Ramos de Andrade, Bruno Costa Martins, Allan Garms Marson, Christiano Vinicius Bernard, Sânia Alves dos Santos, Telesforo Bacchella, Marcel Cerqueira César Machado,