Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3311431 | Hepatology Research | 2006 | 7 Pages |
Abstract
The study groups were obese women with an average body mass index (BMI) of 40.3Â kg/m2, who underwent therapeutic gastroplasty or gastrectomy with a gastro-jejunal anastomosis. Further, the hepatic histology was determined to establish the pathological score grouping the subjects into three categories: control, steatosis and steatohepatitis. The liver CYP2E1 content and the CLZ hydroxylation of obese patients with steatosis and, particularly, with steatohepatitis were significantly higher than controls and correlated positively with both the severity of the liver damage. These data provide evidence that CYP2E1 would be involved in the mechanism of liver injury found in obese NAFLD patients. Also, the correlation between liver CYP2E1 content and in vivo CLZ hydroxylation would validate the latter as a reliable indicator of liver injury in NAFLD, thus providing a simple and not invasive method to study these patients.
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Authors
Myriam Orellana, Ramón Rodrigo, Nelson Varela, Julia Araya, Jaime Poniachik, Attila Csendes, Gladys Smok, Luis A. Videla,