Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
408467 | Neurocomputing | 2007 | 5 Pages |
Abstract
The hyperpolarization-activated mixed cation and the persistent sodium conductances are compared as linearizing mechanisms for somatodendritic synaptic integration in steady-state systems. In the steady-state model used, the persistent sodium conductance creates a well-defined region of linear synaptic excitation, from -66 to -55mV. This corresponds to a moderate level of synaptic depolarization (total active synaptic conductance ranging from 2 to 5.9Â nS). In contrast, a model enhanced with a hyperpolarization-activated mixed cation conductance only linearizes over a short voltage range, from -68 to -61mV. This in turns corresponds to very low levels of synaptic activity (0-3.7Â nS). Given in vivo recordings of firing thresholds for nonbursting neurons ranging from around -60 to -55mV, the persistent sodium current emerges as the better linearizing mechanism for these neurons because it operates across the full physiologically relevant voltage range for perisomatic, proximal dendritic synaptic excitation.
Related Topics
Physical Sciences and Engineering
Computer Science
Artificial Intelligence
Authors
Danielle Morel, William B Levy,