Displaced strategies optimize connectivity in neocortical networks

This study considers the impact of different connection strategies in developing neocortical networks. An adequate connectivity is a requisite for synaptogenesis and the development of synchronous oscillatory network activity during maturation of cortical networks. In a defined time window early in development neurites have to grow out and connect to other neurons. Based on morphological observations we postulate that the underlying mechanism differs from common strategies of unspecific global or small-world strategies. We show that displaced connection strategies are very effective approaches to connect neurons with minimal wiring costs.