Article ID Journal Published Year Pages File Type
408701 Neurocomputing 2006 5 Pages PDF
Abstract

We propose a conductance-based model of a rod photoreceptor cell based on experimental data and other modeling works. In this model we use four types of ionic channels identified in the inner segment of the rod: nonselective cation channel (h), delayed rectifying potassium channel (Kv), noninactivating potassium channel (Kx) and calcium channel (Ca). The model accurately reproduces the rod response when fed with a simulated photocurrent signal. The results show that the initial transient in the voltage response is generated by the h channel. They also show that the h channel has a role in increasing the dynamic range of rod response to light intensity. Since we used a single compartment model and directly injected the photocurrent in this compartment instead of simulating the phototransduction process we produced a model with low computational cost to be used in large-scale retina models.

Related Topics
Physical Sciences and Engineering Computer Science Artificial Intelligence
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