Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
408717 | Neurocomputing | 2006 | 6 Pages |
Abstract
Recent studies of the lamprey spinal cord have shown that hemisegmental preparations can display rhythmic activity in response to a constant input drive. This activity is believed to be generated by a network of recurrently connected excitatory interneurons. A recent study found and characterized self-sustaining rhythmic activity—locomotor bouts—after brief electrical stimulation of hemisegmental preparations. The mechanisms behind the bouts are still unclear. We have developed a computational model of the hemisegmental network. The model addresses the possible involvement of NMDA, AMPA, acetylcholine, and metabotropic glutamate receptors as well as axonal delays in locomotor bouts.
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Artificial Intelligence
Authors
Mikael Huss, Lorenzo Cangiano, Jeanette Hellgren Kotaleski,