Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4395854 | Journal of Experimental Marine Biology and Ecology | 2012 | 5 Pages |
Abstract
⺠DBT is an endocrine disruptor in zebrafish. ⺠In vivo, DBT exposure decreases zfCYP19a, zfERβ1 and FST mRNA in the gonads. ⺠In vitro, DBT exposure inhibits testosterone induced luciferase activity. ⺠In vitro, DBT exposure increases ethinylestradiol induced luciferase activity. ⺠DBT's MOA is complex and may be due to the metabolism of DBT to MBT.
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Authors
Courtney L. McGinnis, P.C. Encarnacao, Joseph F. Crivello,