Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4496184 | Journal of Theoretical Biology | 2014 | 9 Pages |
Abstract
Protein sequences of varying lengths share the same fold and therefore they are very similar (in a fold) if aligned properly. To this, we develop an amino acid alignment method to extract important features from protein sequences by computing dissimilarity distances between proteins. This is done by measuring distance between two respective position specific scoring matrices of protein sequences which is used in a support vector machine framework. We demonstrated the effectiveness of the proposed method on several benchmark datasets. The method shows significant improvement in the fold recognition performance which is in the range of 4.3-7.6% compared to several other existing feature extraction methods.
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Authors
James Lyons, Neela Biswas, Alok Sharma, Abdollah Dehzangi, Kuldip K. Paliwal,