| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4496757 | Journal of Theoretical Biology | 2012 | 16 Pages |
Abstract
⺠Mathematical models allow us to test hypotheses about stem cell behavior. ⺠We model homeostasis and monoclonal conversion in a colonic crypt. ⺠Asymmetric division without feedback cannot produce a stable structured crypt. ⺠Under symmetric division within a stem cell niche, a stable crypt arises naturally. ⺠The spatial structure of a crypt significantly affects the time to monoclonality.
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Authors
Alexander G. Fletcher, Christopher J.W. Breward, S. Jonathan Chapman,