Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4497127 | Journal of Theoretical Biology | 2011 | 12 Pages |
Abstract
Based on available structural studies, a model is presented for polymerization dynamics of mammalian family X DNA polymerases, including polymerases β, λ, μ, and terminal deoxynucleotidyl transferase (TdT). Using the model, distinct polymerization activities and processivities of the four polymerases acting on different forms of DNA substrate are analyzed and studied theoretically. A “gradient” of template dependence of polymerases β, λ, μ, and TdT is well explained. The much higher occurrence frequencies of the â1 frameshift DNA synthesis by pols λ and μ than that by pol β are well explained. The theoretical results on the polymerization processivities are also in agreement with the available experimental data.
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Authors
Ping Xie,