Biologically meaningful update rules increase the critical connectivity of generalized Kauffman networks

Therefore, we study two approaches to increase the critical connectivity. First, we demonstrate that each network can be kept in its frozen regime by sufficiently biasing the update rules. Second, we restrict the randomly chosen update rules to a subclass of biologically more meaningful functions. These functions are characterized based on a thermodynamic model of gene regulation. We analytically show that their usage indeed increases the critical connectivity. From a general point of view, our thermodynamic considerations link discrete and continuous models of gene regulatory networks.