Article ID Journal Published Year Pages File Type
4497459 Journal of Theoretical Biology 2010 7 Pages PDF
Abstract

Hepatitis B virus (HBV) infection is a globally health problem. In 2005, the WHO Western Pacific Regional Office set a goal of reducing chronic HBV infection rate to less than 2% among children five years of age by 2012, as an interim milestone towards the final goal of less than 1%. Many countries made some plans (such as free HBV vaccination program for all neonates in China now) to control the transmission HBV. We develop a model to explore the impact of vaccination and other controlling measures of HBV infection. The model has simple dynamical behavior which has a globally asymptotically stable disease-free equilibrium when the basic reproduction number R0≤1R0≤1, and a globally asymptotically stable endemic equilibrium when R0>1R0>1. Numerical simulation results show that the vaccination is a very effective measure to control the infection and they also give some useful comments on controlling the transmission of HBV.

Related Topics
Life Sciences Agricultural and Biological Sciences Agricultural and Biological Sciences (General)
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