Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4498001 | Journal of Theoretical Biology | 2009 | 10 Pages |
Abstract
Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.
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Authors
Christine Nazaret, Margit Heiske, Kevin Thurley, Jean-Pierre Mazat,