Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4498188 | Journal of Theoretical Biology | 2008 | 10 Pages |
Abstract
In this paper the qualitative dynamic behavior of reaction kinetic models of G protein signaling is examined. A simplified basic G protein signaling structure is defined, which is extended to be able to take the effect of slow transmission, RGS mediated feedback regulation and ERK-phosphatase mediated feedback regulation into account.The resulting model gives rise to an acceptable qualitative approximation of the G protein dependent and independent ERK activation dynamics that is in good agreement with the experimentally observed behavior.
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Authors
Dávid Csercsik, Katalin M. Hangos, György M. Nagy,