Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4498323 | Journal of Theoretical Biology | 2008 | 6 Pages |
Abstract
In this paper, we develop an HIV model that considers the dependence of HIV/AIDS progress on infection age (duration since infection), chronological age and impulsive antiretroviral treatment. The analytical results show that there exists a globally asymptotically stable infection-free state when the impulsive period TT and drug-treatment proportion pp satisfy R0(p,T)<1R0(p,T)<1. The numerical simulation results indicate that there exist TT and pp such that R0(p,T)<1R0(p,T)<1. Due to pulses, it would be difficult to obtain the optimal pulse interval in the age distribution of population. However, our results demonstrate the effect of the impulsive drug-treatment strategy on the dynamics of HIV/AIDS.
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Agricultural and Biological Sciences (General)
Authors
Helong Liu, Jingyuan Yu, Guangtian Zhu,