Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4499383 | Journal of Theoretical Biology | 2006 | 8 Pages |
Abstract
We propose a simple model of pathologic microsatellite expansion, and describe an inherent self-repairing mechanism working against expansion. We prove that if the probabilities of elementary expansions and contractions are equal, microsatellite expansions are always self-repairing. If these probabilities are different, self-reparation does not work. Mosaicism, anticipation and reverse mutation cases are discussed in the framework of the model. We explain these phenomena and provide some theoretical evidence for their properties, for example, the rarity of reverse mutations.
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Authors
Boris Veytsman, Leila Akhmadeyeva,