Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4499484 | Journal of Theoretical Biology | 2006 | 7 Pages |
Abstract
Based on the conservation analysis of the 683 latest experimentally verified Ï70-promoter sequences of Escherichia coli K-12, it is found that the conservative hexamers segments in different sites play a key role of promoter regions, a novel position-correlation scoring matrix (PCSM) algorithm for predicting Ï70 promoter is presented. The predictive capacity of the algorithm is tested by 10-cross validation test. The results show that the overall prediction accuracies (sensitivity) and specificity are 91% and 81%, respectively. By selecting the 683 experimentally verified Ï70 promoters as training set and searching for the complete sequence in E. coli K-12 with 4639221Â bp. Results show that the 100% of the 683 experimentally verified Ï70 promoters have been identified and some possible promoters are predicted.
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Authors
Qian-Zhong Li, Hao Lin,