Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4499575 | Journal of Theoretical Biology | 2006 | 8 Pages |
Abstract
In this study we model a gene network as a continuous-time switching network. In this model, each gene has a binary state which indicates if the gene expresses or not. We propose a method to control a sequence of expression patterns in the gene network model by adding another continuous-time switching network. By using propositional calculus, we will show that the control problem can be formulated as a mixed-integer linear programming problem with linear constraints.
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Agricultural and Biological Sciences (General)
Authors
Hideki Nakayama, Hiroto Tanaka, Toshimitsu Ushio,