Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4502399 | Theoretical Population Biology | 2013 | 11 Pages |
Abstract
We investigate the properties of a Wright–Fisher diffusion process starting at frequency xx at time 0 and conditioned to be at frequency yy at time TT. Such a process is called a bridge. Bridges arise naturally in the analysis of selection acting on standing variation and in the inference of selection from allele frequency time series. We establish a number of results about the distribution of neutral Wright–Fisher bridges and develop a novel rejection-sampling scheme for bridges under selection that we use to study their behavior.
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Authors
Joshua G. Schraiber, Robert C. Griffiths, Steven N. Evans,