Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4502468 | Theoretical Population Biology | 2012 | 7 Pages |
Abstract
We present a method for correcting ascertainment-bias in a coalescent-based likelihood for population trees. Our method is computationally simple and fast. To correct for the bias we compute the probability of allele-counts conditioned on the locus being included. This conditional probability is simply the uncorrected likelihood divided by the inclusion probability. A modification of a pruning algorithm is introduced so that the inclusion probability can be computed with a single run of the algorithm. Our computation is exact and avoids Monte-Carlo based methods.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Agricultural and Biological Sciences (General)
Authors
Arindam RoyChoudhury, Elizabeth A. Thompson,